Hydrochloric Acid → Methyl 5-(methylsulfonyl)-1H-indole-2-carboxylate

HRID 1432249

반응식

HRID 1432249 반응식
[CH3:1][O:2][C:3]([C:5]1[N:6](S(C2C=CC=CC=2)(=O)=O)[C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=2)=[O:4].O1CCCC1.[OH-].[K+].Cl>CO>[CH3:1][O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=2)=[O:4]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14797Potassium HydroxideHCID 684443721-Benzenesulfonyl-5-methanesulfonylindole-2-carboxylic acid methyl ester

생성물 1

HCID 735868Methyl 5-(methylsulfonyl)-1H-indole-2-carboxylate수율 97.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of the resulting 1-benzenesulfonyl-5-methanesulfonylindole-2-carboxylic acid methyl ester (3.5 g), tetrahydrofuran (45 ml) and methanol (12 ml), potassium hydroxide (0.79 g) was added at 0° C. and the mixture was stirred at the same temperature for 3 hours. 2N, hydrochloric acid was added, and the mixture was extracted with dichloromethane. The organic layer was washed with water and dried over sodium sulfate. The solvent was distilled off under reduced pressure to obtain 2.2 g of a white amorphous 5methanesulfonylindole-2-carboxylic acid methyl ester as a crude product.

후처리

  1. additionwas added at 0° C.
  2. extractionthe mixture was extracted with dichloromethane
  3. washThe organic layer was washed with water
  4. dry with materialdried over sodium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-3e06c91d59f744ecbfdea23701b1b44c
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612070B2

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