Sodium Hydroxide → 4,5,6,7-Tetrahydro-1,3-benzothiazole-5-carboxylic acid

HRID 1432351노트

반응식

HRID 1432351 반응식
[OH-].[Na+].[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([O:14]CC)=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1>CO>[S:3]1[C:7]2[CH2:8][CH2:9][CH:10]([C:12]([OH:14])=[O:13])[CH2:11][C:6]=2[N:5]=[CH:4]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 13424804HCID 13424804, 화합물

생성물 1

HCID 685523074,5,6,7-Tetrahydro-1,3-benzothiazole-5-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6 ml of 2N NaOH are added to a solution of 0.42 g of ethyl 4,5,6,7-tetrahydrobenzothiazole-5-carboxylate [952203-30-8] and 24 ml of MeOH at room temperature. After 6 hours, the reaction mixture is evaporated. The residue is acidified with 4N HCl, diluted with water and extracted with ethyl acetate (2×)—the combined organic phases are dried with sodium sulphate and evaporated. The crude title compound is obtained from the residue.

후처리

  1. customthe reaction mixture is evaporated
  2. additiondiluted with water
  3. extractionextracted with ethyl acetate (2×)—the combined organic phases
  4. dry with materialare dried with sodium sulphate
  5. customevaporated

출처 및 근거

ORD 기록
ord-2d395f3bf35e485a8aeafc3f85cc22c1
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612088B2

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