N-bromobutanimide → N-{5-[8-(1-Ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazin-3-yl]-4-methyl-oxazol-2-yl}-dimethylamine

HRID 1432596노트

반응식

HRID 1432596 반응식
[CH2:1]([CH:3]([C:6]1[C:7]2[N:8]([C:13]([C:17]3[O:21][CH:20]=[N:19][C:18]=3[CH3:22])=[C:14]([CH3:16])[N:15]=2)[N:9]=[C:10]([CH3:12])[CH:11]=1)[CH2:4][CH3:5])[CH3:2].C1[C:28](=O)[N:27](Br)[C:25](=O)C1>C(Cl)Cl>[CH2:1]([CH:3]([C:6]1[C:7]2[N:8]([C:13]([C:17]3[O:21][C:20]([N:27]([CH3:28])[CH3:25])=[N:19][C:18]=3[CH3:22])=[C:14]([CH3:16])[N:15]=2)[N:9]=[C:10]([CH3:12])[CH:11]=1)[CH2:4][CH3:5])[CH3:2]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 579329208-(1-Ethyl-propyl)-2,6-dimethyl-3-(4-methyl-oxazol-5-yl)-imidazo[1,2-b]pyridazine

생성물 1

HCID 57932997N-{5-[8-(1-Ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazin-3-yl]-4-methyl-oxazol-2-yl}-dimethylamine수율 13.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

230 mg of 8-(1-Ethyl-propyl)-2,6-dimethyl-3-(4-methyl-oxazol-5-yl)-imidazo[1,2-b]pyridazine (0.77 mmol) is dissolved in 20 ml of CH2Cl2 and 178 mg of NBS (1.0 mmol) is added. The reaction mixture is stirred at room temperature overnight. The reaction mixture is washed with sat. Na2S2O3, sat. NaCl, dried over Na2SO4 and evaporated. The crude product is applied onto a silica-gel chromatography column (Hexane:AcOEt=3:1) to give 36 mg of the title compound. Yield 12%. mass spectrum (m/e): 378 (M+1). 1H-NMR (CDCl3): 6.82 (s, 1H), 3.39 (m, 1H), 2.58 (s, 3H), 2.53 (s, 3H), 2.26 (s, 3H), 1.85 (m, 1H), 0.89 (t, J=7.4 Hz, 6H).

후처리

  1. washThe reaction mixture is washed with sat. Na2S2O3, sat. NaCl
  2. dry with materialdried over Na2SO4
  3. customevaporated

출처 및 근거

ORD 기록
ord-70bb00d547da40ecaf62391e8f974291
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612067B2

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