Sodium borohydride → HCID 54519295, 화합물

HRID 1432955노트

반응식

HRID 1432955 반응식
[BH4-].[Na+].[C:3]([O:7][C:8]([N:10]1[C:18]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[CH:12]=[C:11]1[CH2:19][N:20]1[C:25](=[O:26])[CH2:24][N:23]([S:27]([CH:30]=[CH:31][C:32]2[S:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:29])=[O:28])[CH2:22][CH:21]1[C:38](OC)=[O:39])=[O:9])([CH3:6])([CH3:5])[CH3:4].C(OC(N1C2C=CN=CC=2C=C1CN1C(=O)CNCC1C(OC)=O)=O)(C)(C)C.ClC1SC(C=CS(Cl)(=O)=O)=CC=1>CO>[C:3]([O:7][C:8]([N:10]1[C:18]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[CH:12]=[C:11]1[CH2:19][N:20]1[C:25](=[O:26])[CH2:24][N:23]([S:27]([CH:30]=[CH:31][C:32]2[S:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:29])=[O:28])[CH2:22][CH:21]1[CH2:38][OH:39])=[O:9])([CH3:5])([CH3:6])[CH3:4]

참가 물질

6

반응물 4

HCID 4311764Sodium borohydrideHCID 54182443HCID 54182443, 화합물HCID 544630642-(5-Chlorothiophen-2-yl)ethenesulfonyl chlorideHCID 69028555HCID 69028555, 화합물

생성물 1

HCID 54519295HCID 54519295, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Sodium borohydride (0.005 g, 0.13 mmol) is added to a solution of 2-{4-[2-(5-chloro-thiophen-2-yl)-ethenesulfonyl]-2-(±)-methoxycarbonyl-6-oxo-piperazin-1-ylmethyl}-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (0.04 g, 0.07 mmol), (prepared from 2-(2-(±)-methoxycarbonyl-6-oxo-piperazin-1-ylmethyl)-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester, EXAMPLE 71, and 2-(5-chloro-thiophen-2-yl)-ethenesulfonyl chloride, EXAMPLE 3, using the procedure described in EXAMPLE 214, Part A) in MeOH (3 mL) at RT. The reaction mixture is stirred for 6 h then quenched with water and concentrated in vacuo. The crude product (0.04 g) is taken onto the next step without further purification.

후처리

  1. customat RT
  2. customthen quenched with water
  3. concentrationconcentrated in vacuo
  4. customThe crude product (0.04 g) is taken onto the next step without further purification

출처 및 근거

ORD 기록
ord-bee0f9d895c041f8850757b9cd95aef4
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612075B2

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