Trifluoroacetic acid → 4-(4-Amino-quinazolin-7-ylmethyl)-2-(S)-methoxymethyl-3-oxo-piperazine-1-carboxylic acid (4-chloro-phenyl)-amide
반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH:15]([CH2:19][O:20][CH3:21])[C:14]3=[O:22])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[O:32])=[CH:26][CH:25]=1.C(O)(C(F)(F)F)=O>>[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([NH:30][C:31]([N:16]2[CH2:17][CH2:18][N:13]([CH2:12][C:8]3[CH:7]=[C:6]4[C:11]([C:2]([NH2:1])=[N:3][CH:4]=[N:5]4)=[CH:10][CH:9]=3)[C:14](=[O:22])[C@@H:15]2[CH2:19][O:20][CH3:21])=[O:32])=[CH:26][CH:25]=1참가 물질
4
실험 절차
The title compound is prepared as described in EXAMPLE 436 using 1-(4-amino-quinazoline-7-ylmethyl)-3-methoxymethyl-piperazine-2-one, EXAMPLE 75, and 4-chlorophenyl isocyanate. 1H NMR (DMSO-d6, 300 MHz) δ9.77 (bs, 2H), 8.81 (s, 1H), 8.70 (s, 1H), 8.40 (d, 1H), 7.64 (d, 1H), 7.61 (s, 1H), 7.49 (d, 2H), 7.28 (d, 2H), 4.88 (m, 1H), 4.80 (AB, 2H), 4.19 (m, 1H), 3.96 (m, 1H), 3.74-3.42 (m, 4H), 3.28 (s, 3H). ESI MS, [M+H]+=455,457 (Cl pattern). Anal. (C22H23ClN6O3.TFA.1.5H2O) C, H, N.
출처 및 근거
- ORD 기록
- ord-b6ef8c62420c4e4792e3289df1f143d5
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07612075B2
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