N-bromobutanimide → N-(4-Acetyl-5-benzyloxy-2-bromo-phenyl)-acetamide

HRID 1433158노트

반응식

HRID 1433158 반응식
[Br:1]N1C(=O)CCC1=O.[C:9]([C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:21])[CH3:20])=[CH:14][C:13]=1[O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:11])[CH3:10]>CN(C=O)C.C(Cl)Cl>[C:9]([C:12]1[C:13]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:14][C:15]([NH:18][C:19](=[O:21])[CH3:20])=[C:16]([Br:1])[CH:17]=1)(=[O:11])[CH3:10]

참가 물질

5

반응물 2

HCID 67184N-bromobutanimideHCID 69059816HCID 69059816, 화합물

생성물 1

HCID 69059837N-(4-Acetyl-5-benzyloxy-2-bromo-phenyl)-acetamide수율 67.1%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

실험 절차

N-Bromosuccinimide (0.756 g, 4.27 mmol) was added portionwise to a solution of N-(4-acetyl-3-benzyloxy-phenyl)-acetamide (1.2 g, 4.24 mmol) in DMF (24 ml) and the reaction stirred overnight at room temperature. The reaction mixture was diluted with DCM, washed with water and dried over MgSO4 to afford a white solid (1.03 g, 67%). LC/MS: RT=2.609 min. 362/364 (MH+).

후처리

  1. washwashed with water
  2. dry with materialdried over MgSO4

출처 및 근거

ORD 기록
ord-9d97553c2d624c769969abffaf78e1f5
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612201B2

반응 노트

불러오는 중…