Sodium Hydroxide → HCID 22936638, 화합물

HRID 1433368노트

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HRID 1433368 반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]C)=[O:18])[N:9]=[CH:8][CH:7]=[C:6]2[O:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]([NH:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)=[O:30])=[CH:24][CH:23]=1)#[N:2].[OH-].[Na+]>CO>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[N:9]=[CH:8][CH:7]=[C:6]2[O:21][C:22]1[CH:23]=[CH:24][C:25]([NH:28][C:29]([NH:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)=[O:30])=[CH:26][CH:27]=1)#[N:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10143024HCID 10143024, 화합물

생성물 1

HCID 22936638HCID 22936638, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
80 °C

실험 절차

N-(4-(6-Cyano-7-(3-methoxycarbonylpropoxy)-4-quinolyl)oxyphenyl)-N′-(4-methoxyphenyl)urea (100 mg) was added to a methanol (16 ml) and 2N aqueous sodium hydroxide (3 ml) mixed solvent, and the mixture was heated and stirred at 80° C. for 35 minutes. The reaction solution was filtered, and then 1.2 ml of aqueous 5N hydrochloric acid was added. The precipitated solid was filtered out and washed with methanol and then ether to obtain 50 mg of the target substance as a light yellow solid.

후처리

  1. additionmixed solvent
  2. temperaturethe mixture was heated
  3. filtrationThe reaction solution was filtered
  4. addition1.2 ml of aqueous 5N hydrochloric acid was added
  5. filtrationThe precipitated solid was filtered out
  6. washwashed with methanol
  7. customether to obtain 50 mg of the target substance as a light yellow solid

출처 및 근거

ORD 기록
ord-a11fc46b7ac14a07999fbccd8698ec23
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612092B2

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