Methanesulfonyl chloride → Ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

HRID 14335노트

반응식

HRID 14335 반응식
[NH2:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.C(N(CC)C(C)C)(C)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>ClCCl>[CH3:21][S:22]([NH:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1)(=[O:24])=[O:23]

참가 물질

5

반응물 3

HCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 319549Ethyl 2-amino-1,3-oxazole-4-carboxylate

생성물 1

HCID 21086093Ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a 20 ml screw cap vial was added (1 g, 5.8069 mmoles) ethyl 2-amino-1,3-oxazole-4-carboxylate, (10 ml) dichloromethane and (1.39 ml, 7.9797 mmoles, 1.25 eq.) N,N-diisopropylethylamine. To the reaction was then added (0.545 ml, 7.0415 mmoles, 1.1 eq.) methanesulfonyl chloride, and the reaction was agitated for 14 hours. The reaction was then evaporated to dryness and purified using a Biotage silica gel column, resulting in (272 mg) of ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate.

후처리

  1. customTo a 20 ml screw cap
  2. customThe reaction was then evaporated to dryness
  3. custompurified
  4. customresulting in (272 mg) of ethyl 2-[(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

출처 및 근거

ORD 기록
ord-d9638ebdcd4f4839b8b9e1f57a937acf
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

반응 노트

불러오는 중…