4-Bromo-3-nitrobenzotrifluoride → 7-Methoxy-3-(2-nitro-4-trifluoromethylphenyl)-1,2-dihydronaphthalene

HRID 1433868

반응식

HRID 1433868 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].C([Sn](CCCC)(CCCC)C1C=CC(C(F)(F)F)=CC=1[N+]([O-])=O)CCC.FC(F)(F)S(O[C:47]1[CH2:56][CH2:55][C:54]2[C:49](=[CH:50][CH:51]=[C:52]([O:57][CH3:58])[CH:53]=2)[CH:48]=1)(=O)=O>>[CH3:58][O:57][C:52]1[CH:53]=[C:54]2[C:49]([CH:48]=[C:47]([C:2]3[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=3[N+:12]([O-:14])=[O:13])[CH2:56][CH2:55]2)=[CH:50][CH:51]=1

참가 물질

4

반응물 3

HCID 5207064-Bromo-3-nitrobenzotrifluorideHCID 153302566-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonateHCID 23087363Tributyl(2-nitro-4-trifluoromethylphenyl)tin

생성물 1

HCID 230874677-Methoxy-3-(2-nitro-4-trifluoromethylphenyl)-1,2-dihydronaphthalene

실험 절차

Synthesized from 1-bromo-2-nitro-4-trifluoromethylbenzene according to an analogous synthetic method to Preparation Example 76, tributyl(2-nitro-4-trifluoromethylphenyl)tin (7.4 g) and 6-methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate (2.2 g) were used according to an analogous synthetic method to Preparation Example 77 to provide 7-methoxy-3-(2-nitro-4-trifluoromethylphenyl)-1,2-dihydronaphthalene (1.5 g). The total amount of this compound was used according to an analogous synthetic method to Example 30 to provide the title compound (1.0 g).

후처리

  1. customwere used according to an analogous synthetic method to Preparation Example 77

출처 및 근거

ORD 기록
ord-d00daee45e914c9cbcda05ad34a62def
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612114B2

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