Pyrrolidine → Ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl](2-pyrrolidin-1-ylethyl)amine
반응식
ClCC(N(CC)C1C=C(OC)C=CC=1C1CCC2C(=CC=C(OC)C=2)C1)=O.N1CCCC1.[CH2:33]([N:35]([C:44]1[CH:49]=[C:48]([O:50][CH3:51])[CH:47]=[CH:46][C:45]=1[CH:52]1[CH2:61][CH2:60][C:59]2[C:54](=[CH:55][CH:56]=[C:57]([O:62][CH3:63])[CH:58]=2)[CH2:53]1)[C:36](=O)[CH2:37][N:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1)[CH3:34]>>[CH2:33]([N:35]([C:44]1[CH:49]=[C:48]([O:50][CH3:51])[CH:47]=[CH:46][C:45]=1[CH:52]1[CH2:61][CH2:60][C:59]2[C:54](=[CH:55][CH:56]=[C:57]([O:62][CH3:63])[CH:58]=2)[CH2:53]1)[CH2:36][CH2:37][N:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1)[CH3:34]참가 물질
4
반응물 3
생성물 1
실험 절차
Synthesized from 2-chloro-N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]acetamide and pyrrolidine according to an analogous synthetic method to Preparation EXAMPLE 89, N-ethyl-N-[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]-2-pyrrolidin-1-ylacetamide (119 mg) was used according to an analogous synthetic method to Example 337 described below to provide ethyl [5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl](2-pyrrolidin-1-ylethyl)amine (96 mg). This compound (95 mg) was used according to an analogous synthetic method to Example 111 described below to provide the title compound (92 mg).
출처 및 근거
- ORD 기록
- ord-17b319a699e14a79b744b5fee645c2e6
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07612114B2
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