Sodium borohydride → HCID 68704632, 화합물

HRID 1434591노트

반응식

HRID 1434591 반응식
[BH4-].[Na+].[CH3:3][S:4]([C:7]1[CH:31]=[CH:30][C:10]2[N:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[O:23])[CH2:16][CH2:15]3)[CH:12]=[N:13][C:9]=2[CH:8]=1)(=[O:6])=[O:5]>C(O)C>[CH3:3][S:4]([C:7]1[CH:31]=[CH:30][C:10]2[N:11]([CH:14]3[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[OH:23])[CH2:16][CH2:15]3)[CH:12]=[N:13][C:9]=2[CH:8]=1)(=[O:6])=[O:5]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 57935976HCID 57935976, 화합물

생성물 1

HCID 68704632HCID 68704632, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium borohydride (189 mg) was added to a solution of 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-one (2.07 g) in ethanol (40 ml) at 0° C., the mixture was allowed to warm to room temperature and was stirred for 16 hours. The reaction mixture was evaporated to dryness, the residue was redissolved in dichloromethane and washed with water (15 ml) and brine (15 ml) and dried. Removal of the solvent gave 3-{4-[5-(methylsulfonyl)-1H-benzimidazol-1-yl]piperidin-1-yl}-1-phenylpropan-1-ol, 2.1 g, M+H 414.

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. dissolutionthe residue was redissolved in dichloromethane
  3. washwashed with water (15 ml) and brine (15 ml)
  4. customdried
  5. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-3ae6950eaf34440caacf3571db161d47
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615555B2

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