Methyl iodide → 3-(t-Butoxycarbonylamino)-2-methoxypropyl Triisopropylsilyl Ether

반응식

[CH:1]([Si:4]([O:11][CH2:12][CH:13]([OH:23])[CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([CH:8]([CH3:10])[CH3:9])[CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].[CH3:24]I>>[CH:8]([Si:4]([O:11][CH2:12][CH:13]([O:23][CH3:24])[CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])([CH:5]([CH3:7])[CH3:6])[CH:1]([CH3:3])[CH3:2])([CH3:9])[CH3:10]

참가 물질

반응물 2

HCID 6328Methyl iodide

HCID 579366063-(t-Butoxycarbonylamino)-2-hydroxypropyl Triisopropylsilyl Ether

생성물 1

HCID 579365643-(t-Butoxycarbonylamino)-2-methoxypropyl Triisopropylsilyl Ether수율 62%

실험 절차

Using a procedure analogous to Example 57-B, 3-(t-butoxycarbonylamino)-2-hydroxypropyl triisopropylsilyl ether and methyl iodide gave the title compound (13 g, 62%).

출처 및 근거

ORD 기록: ord-d4197aed26de4ca885f5552edc3b8199
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07615568B2

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