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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1435236생성일: 2026년 10월 26일

Thiophene-3-sulfonyl Chloride → [4-Amino-2-[1-(thiophene-3-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone

https://huagongshe.com/reaction/1435236

반응식

참여 물질

역할이름HCID투입량
반응물Thiophene-3-sulfonyl ChlorideHCID 2776378—
반응물[4-Amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanoneHCID 9997668—
생성물[4-Amino-2-[1-(thiophene-3-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanoneHCID 58777610—

반응 단계

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone, Example 59, and 3-thiophenesulfonyl chloride (Maybridge) by the procedure described in Example 152. HR-MS (ES, m/z) calculated for C21H23FN5O4S2 [(M+H)+] 492.1170, observed 492.1175.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07615634B2
출처 데이터셋uspto-grants-2009_11
ORD IDord-c85ca3cd9bf940e9a1b07c3c888dbfcf
출처 메모uspto-grants-2009_11