Diisopropylethylamine → HCID 69013806, 화합물

HRID 1435347노트

반응식

HRID 1435347 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([S:8]([CH3:11])(=[O:10])=[O:9])[CH2:4][CH:3]1[OH:12].[NH2:13][C:14]1[C:19]([C:20]([C:22]2[C:27]([O:28][CH3:29])=[CH:26][CH:25]=[C:24]([F:30])[C:23]=2[F:31])=[O:21])=[CH:18][N:17]=[C:16](Cl)[N:15]=1.C(N(C(C)C)CC)(C)C>C(O)C>[NH2:13][C:14]1[C:19]([C:20]([C:22]2[C:27]([O:28][CH3:29])=[CH:26][CH:25]=[C:24]([F:30])[C:23]=2[F:31])=[O:21])=[CH:18][N:17]=[C:16]([NH:1][CH:2]2[CH2:7][CH2:6][N:5]([S:8]([CH3:11])(=[O:10])=[O:9])[CH2:4][CH:3]2[OH:12])[N:15]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 21070550HCID 21070550, 화합물HCID 21070647HCID 21070647, 화합물

생성물 1

HCID 69013806HCID 69013806, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The amine (44 mg, 0.22 mmol, Example 305) and chloropyrimidine (55 mg, 0.18 mmol, Example 289) were dissolved in ethanol (5 mL). To the stirred mixture at reflux, diisopropylethylamine (64 uL, Aldrich) was added and the mixture was refluxed for 20 hours. The solvent was removed and the residue was purified by HPLC (10-60%, acetonitrile/water) to give a white solid, 25 mg, 30%. MS (ES) MH+=458.

후처리

  1. temperatureTo the stirred mixture at reflux
  2. temperaturethe mixture was refluxed for 20 hours
  3. customThe solvent was removed
  4. customthe residue was purified by HPLC (10-60%, acetonitrile/water)
  5. customto give a white solid, 25 mg, 30%

출처 및 근거

ORD 기록
ord-c796912d74da42b39ea89c85789b7654
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615634B2

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