4-Bromoaniline → HCID 10179730, 화합물

HRID 1435735

반응식

HRID 1435735 반응식
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=2[CH3:16])[N:3]=1.[Br:17][C:18]1[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=1.O1CCCC1.C(N(C(C)C)CC)(C)C>ClCCl>[Br:17][C:18]1[CH:24]=[CH:23][C:21]([NH:22][C:2]2[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]3[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=3[CH3:16])[N:3]=2)=[CH:20][CH:19]=1

참가 물질

6

반응물 4

HCID 78074-BromoanilineHCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 858270322,4-Dichloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine

생성물 1

HCID 10179730HCID 10179730, 화합물수율 86%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 2,4-dichloro-6-(5-chloro-2-methyl-phenyl)-[1,3,5]triazine (2.5 g, 9.1 mmol), 4-bromoaniline (1.6 g, 9.3 mmol), tetrahydrofuran (60 ml), and diisopropylethylamine (1.6 ml, 9.2 mmol) was stirred for 1 hour. The solution was treated with dichloromethane (200 ml), washed with saturated aqueous sodium chloride solution (50 ml), and concentrated under reduced pressure. The residual solid was treated with hydrochloric acid (1 M, 25 ml) and stirred vigorously for 30 minutes. Filtration and drying under reduced pressure provided the title compound (3.2 g, 86% yield). 1H NMR (DMSO-d6) 10.75-10.80 (m, 1H), 7.85-7.92 (m, 1H), 7.50-7.65 (m, 4H), 7.40 (m, 1H), 2.58 (s, 3H).

후처리

  1. washwashed with saturated aqueous sodium chloride solution (50 ml)
  2. concentrationconcentrated under reduced pressure
  3. additionThe residual solid was treated with hydrochloric acid (1 M, 25 ml)
  4. stirringstirred vigorously for 30 minutes
  5. filtrationFiltration
  6. customdrying under reduced pressure

출처 및 근거

ORD 기록
ord-478b19e2f94f4a4bb0324881034c6054
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618968B2

연결된 노트

불러오는 중…