Hydrazine hydrate (1:1) → 5-Chloropyrazine-2-carbohydrazide

HRID 1435782노트

반응식

HRID 1435782 반응식
C[O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([Cl:11])=[CH:7][N:6]=1)=O.O.[NH2:13][NH2:14]>CO>[Cl:11][C:8]1[N:9]=[CH:10][C:5]([C:3]([NH:13][NH2:14])=[O:2])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 406081Methyl 5-chloropyrazine-2-carboxylate

생성물 1

HCID 457897975-Chloropyrazine-2-carbohydrazide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

5-chloro-pyrazine-2-carboxylic acid methyl ester (10.02 g, 58.25 mmol) and hydrazine monohydrate (12.5 mL, 250 mmol) were dissolved in methanol (400 mL) and the reaction mixture heated to reflux for 48 hours. The reaction mixture was then filtered and the precipitate collected dried in vacuo to yield the title compound, 5.01 g (50%).

후처리

  1. temperaturethe reaction mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationThe reaction mixture was then filtered
  4. customthe precipitate collected
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-90f36bffd1c045c7b8c2b08a54a649d1
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618972B2

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