Hydrochloric Acid → 5-bromo-6-hydroxy-2H-isoquinolin-1-one

HRID 1436014노트

반응식

[Br:1][C:2]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[C:7]2Cl.Cl.C[OH:16]>>[Br:1][C:2]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][NH:6][C:7]2=[O:16]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 1363374885-Bromo-1-chloro-6-hydroxyisoquinoline

생성물 1

HCID 688728585-bromo-6-hydroxy-2H-isoquinolin-1-one

반응 조건

온도: 150 °C

실험 절차

5-Bromo-1-chloro-6-hydroxyisoquinoline (108 mg, 0.42 mmol) was mixed with hydrochloric acid (5M, 2 ml) and heated under microwave conditions at 150° C. for 40 minutes. The cooled residue was mixed with methanol and azeotroped to dryness under reduced pressure to give 5-bromo-6-hydroxy-2H-isoquinolin-1-one El-MS: m/z=240 and 242[M+H]+.

후처리

customazeotroped to dryness under reduced pressure

출처 및 근거

ORD 기록: ord-6c67a5743af24c3085cab17c36ada983
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07618985B2

반응 노트

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