Hydrochloride methanol → Hydrochloric Acid

HRID 1436050노트

반응식

HRID 1436050 반응식
C(OC([NH:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:29].CO>>[NH2:8][CH:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:15])=[O:16])[CH2:10]1.[ClH:29]

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 67243409(r/s)-3-(Tert-butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)-pyrrolidine

생성물 2

HCID 313Hydrochloric AcidHCID 67242686(r/s)-3-Amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

실험 절차

Intermediate 28 (30 mg) obtained in Step A mentioned above is added with 10% hydrogen chloride/methanol (4 ml), and the mixture is stirred at room temperature for 20 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (25 mg (predictive yield)).

후처리

  1. customThe solvent is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-64145771ea8e43808e68985d8cdf132d
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618984B2

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