Diethyl Oxalate → 4-(3,4,5-Trifluorobenzyl)morpholine-2,3-dione

HRID 1436084

반응식

HRID 1436084 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:14])[C:12]=1[F:13])[CH2:5][NH:6]CCO.[C:15]([O:22][CH2:23][CH3:24])(=[O:21])[C:16]([O:18]CC)=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:14])[C:12]=1[F:13])[CH2:5][N:6]1[CH2:24][CH2:23][O:22][C:15](=[O:21])[C:16]1=[O:18]

참가 물질

3

반응물 2

HCID 7268Diethyl OxalateHCID 63050512HCID 63050512, 화합물

생성물 1

HCID 690103374-(3,4,5-Trifluorobenzyl)morpholine-2,3-dione

반응 조건

온도
170 °C

실험 절차

A mixture of 2-[(3,4,5-trifluorobenzyl)amino]ethanol (6.91 g) and diethyl oxalate (20 mL) was stirred at 170° C. for one hour. The reaction solution was concentrated under reduced pressure, and then a diethyl ether was added to the residue. The precipitated crystals were collected by filtration and then air-dried to obtain 7.38 g of the title compound.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. additiona diethyl ether was added to the residue
  3. filtrationThe precipitated crystals were collected by filtration
  4. customair-dried

출처 및 근거

ORD 기록
ord-94e074c546c94546a00db6bf96662b77
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618960B2

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