Acetyl chloride → N-(5-Nitro-1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide

HRID 1436308노트

반응식

HRID 1436308 반응식
[C:1]([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][CH:11]=[C:7]([C:8]([OH:10])=O)[C:6]=1[C:17]([OH:19])=[O:18])(=[O:3])[CH3:2].C(Cl)(=O)C>C(OC(=O)C)(=O)C>[C:1]([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][CH:11]=[C:7]2[C:8]([O:19][C:17](=[O:18])[C:6]=12)=[O:10])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 155118403-Acetamido-4-nitrophthalic acid

생성물 1

HCID 15511835N-(5-Nitro-1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide수율 58%

시약·촉매·용매 1

HCID 7918Acetic Anhydride용매

실험 절차

3-Acetamido-4-nitrophthalic acid (0.538 g, 2.00 mmol) was dissolved in acetic anhydride (10 ml) at 80° C., and the solution was added with acetyl chloride (1 ml) and stirred for 2 hours. The solvent was evaporated, and a small amount of anhydrous dichloromethane was added to the residue, and precipitates were collected by filtration to obtain the title compound (0.29 g, 58%).

후처리

  1. customThe solvent was evaporated
  2. additiona small amount of anhydrous dichloromethane was added to the residue
  3. customprecipitates
  4. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-76d22a051a794752a369d8bc384c5ab5
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618997B2

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