Hydrogen Bromide → 2-Bromo-4-(4-chloro-3-fluorophenyl)-1,3-thiazole

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][S:10][C:11]#[N:12])=[CH:4][C:3]=1[F:14].[BrH:15]>>[Br:15][C:11]1[S:10][CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([F:14])[CH:4]=2)[N:12]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 866186171-(4-Chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone

생성물 1

HCID 689031182-Bromo-4-(4-chloro-3-fluorophenyl)-1,3-thiazole수율 68%

실험 절차

In the same manner as described in step 5 of Example 78, using 1-(4-chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone (2.45 g, 10.7 mmol), prepared in the previous step, and hydrogen bromide (30% in acetic acid, 16 mL), the solid was collected by suction filtration to give 2-bromo-4-(4-chloro-3-fluorophenyl)-1,3-thiazole (2.1 g, 68%). The material was used without further purification, MS (ES) m/z 293[M+H+].

후처리

filtrationthe solid was collected by suction filtration

출처 및 근거

ORD 기록: ord-7b5dcaa899074c9fa5e490f8bc29c539
출처 데이터셋: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07618990B2

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