Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetic Acid → 3-Bromo-4-fluoro-5-methanesulfonylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetic Acid | HCID 300 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | sodium thiosulfite anhydrous | HCID 15847209 | — |
| 반응물 | 3-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid | HCID 50998480 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-Bromo-4-fluoro-5-methanesulfonylbenzoic acid | HCID 68814711 | — |
반응 단계
To sodium thiosulfite (2.6 g, 20.7 mmol) and sodium bicarbonate (1.74 g, 20.7 mmol) in water (20 mL) at 75° C. add 3-bromo-5-chlorosulfonyl-4-fluorobenzoic acid (6.25 g, 19.7 mmol) in portions over 5 min. After 1 h, cool to room temperature and add chloroacetic acid (5.29 g, 56 mmol) and NaOH (1.18 g, 29.5 mmol) and reflux 16 h. Cool to room temperature and collect the title compound as a solid
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07618978B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-e399c86df21841eeb6b0c4feb724ebe2 |
| 출처 메모 | uspto-grants-2009_11 |