Chloroacetic Acid → 3-Bromo-4-fluoro-5-methanesulfonylbenzoic acid

HRID 1436654노트

반응식

HRID 1436654 반응식
S([O-])([O-])=S.[Na+].[Na+].[C:7](=O)(O)[O-].[Na+].[Br:12][C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([S:23](Cl)(=[O:25])=[O:24])[C:21]=1[F:22])[C:16]([OH:18])=[O:17].ClCC(O)=O.[OH-].[Na+]>O>[Br:12][C:13]1[CH:14]=[C:15]([CH:19]=[C:20]([S:23]([CH3:7])(=[O:25])=[O:24])[C:21]=1[F:22])[C:16]([OH:18])=[O:17]

참가 물질

7

반응물 5

HCID 300Chloroacetic AcidHCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 15847209sodium thiosulfite anhydrousHCID 509984803-Bromo-4-fluoro-5-(chlorosulfonyl)benzoic acid

생성물 1

HCID 688147113-Bromo-4-fluoro-5-methanesulfonylbenzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To sodium thiosulfite (2.6 g, 20.7 mmol) and sodium bicarbonate (1.74 g, 20.7 mmol) in water (20 mL) at 75° C. add 3-bromo-5-chlorosulfonyl-4-fluorobenzoic acid (6.25 g, 19.7 mmol) in portions over 5 min. After 1 h, cool to room temperature and add chloroacetic acid (5.29 g, 56 mmol) and NaOH (1.18 g, 29.5 mmol) and reflux 16 h. Cool to room temperature and collect the title compound as a solid

후처리

  1. temperaturereflux 16 h
  2. temperatureCool to room temperature
  3. customcollect the title compound as a solid

출처 및 근거

ORD 기록
ord-e399c86df21841eeb6b0c4feb724ebe2
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618978B2

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