Trimethyl orthoformate → HCID 23137711, 화합물

HRID 1436893노트

반응식

HRID 1436893 반응식
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15]C(=O)[CH2:13][CH:12]1[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=1[CH3:25])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO[CH:28]([O:31][CH3:32])[O:29][CH3:30]>CO>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][C:28]([O:29][CH3:30])([O:31][CH3:32])[CH2:13][CH:12]1[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=1[CH3:25])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 9005Trimethyl orthoformateHCID 21927685HCID 21927685, 화합물

생성물 1

HCID 23137711HCID 23137711, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 132 g of 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxopiperidine were added 650 ml of methanol, 84 ml of trimethoxymethane and 2 g of strongly acidic resin IR-120 (manufactured by Japan Organo Co., Ltd.), and the mixture was stirred at room temperature for 3 days. From the reaction mixture was removed insoluble matters by filtration, and the solvent was removed by distillation under reduced pressure, to give 146 g of 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4,4-dimethoxypiperidine as shown in Table 125 below.

후처리

  1. customFrom the reaction mixture was removed insoluble matters
  2. filtrationby filtration
  3. customthe solvent was removed by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-eaad82ecf3334b43a61336aa5a4336d1
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07619092B2

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