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Sodium Iodide → HCID 68896791, 화합물

HRID 1437157
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HRID 1437157 반응식
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:6]1.[CH3:20][O:21][C:22](=[O:31])[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29]Br)[CH:24]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CCCC(=O)C.O>[CH3:20][O:21][C:22](=[O:31])[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][N:17]2[CH2:18][CH2:19][CH:14]([C:7]3[C:8]4[C:9](=[N:10][CH:11]=[CH:12][CH:13]=4)[N:5]([CH2:4][CH2:3][O:2][CH3:1])[CH:6]=3)[CH2:15][CH2:16]2)[CH:24]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 517981Methyl 3-(bromomethyl)benzoateHCID 179729681-(2-Methoxyethyl)-3-(4-piperidinyl)-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 68896791HCID 68896791, 화합물

시약·촉매·용매 2

HCID 962Water용매
HCID 7895
2-Pentanone
용매

실험 절차

0.42 g (1.62 mmol) of 1-(2-methoxyethyl)-3-piperidin-4-yl-1H-pyrrolo[2,3-b]pyridine and 0.45 g (1.94 mmol) of 3-bromomethylbenzoic acid methyl ester were solved in 9 ml of 4-methyl-2-butanone and 0.67 g (4.86 mmol) of potassium carbonate and 0.02 g (0.16 mmol) of sodium iodide were added. The mixture was refluxed for 18 hours and, after cooling, water was added, the organic layer separated and washed with water and brine. The solvent was distilled off. The crude material weighed 0.67 g and was used in the following step without further purification.

후처리

  1. temperatureThe mixture was refluxed for 18 hours
  2. temperatureafter cooling
  3. customthe organic layer separated
  4. washwashed with water and brine
  5. distillationThe solvent was distilled off
  6. customwas used in the following step without further purification

출처 및 근거

ORD 기록
ord-e23d88f43dec47969ad2636fed30309e
출처 데이터셋
uspto-grants-2009_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07622480B2

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