Hydrochloric Acid → 1,4-Diazepan-5-one--hydrogen chloride (1/1)
반응식
[ClH:1].C([N:9]1[CH2:15][CH2:14][C:13](=[O:16])[NH:12][CH2:11][CH2:10]1)C1C=CC=CC=1.[H][H]>C(O)C.CO.[C].[Pd]>[ClH:1].[NH:9]1[CH2:15][CH2:14][C:13](=[O:16])[NH:12][CH2:11][CH2:10]1참가 물질
7
실험 절차
1M HCl in ethanol (7.2 mL) and 10% palladium-carbon (0.34 g) were added to 1-benzylhexahydro-1H-1,4-diazepin-5-one (1.490 g) in methanol (10 mL) at room temperature, and the resultant mixture was stirred in a hydrogen atmosphere for 4 hours. After the reaction atmosphere was purged with nitrogen, insoluble matter was removed by filtration. The solvent of the filtrate was evaporated under reduced pressure, and diethyl ether was added to the residue, and then the precipitated solid was recovered by filtration, to thereby give the title compound (1.045 g, 96%).
후처리
- customAfter the reaction atmosphere
- customwas purged with nitrogen, insoluble matter
- customwas removed by filtration
- customThe solvent of the filtrate was evaporated under reduced pressure, and diethyl ether
- additionwas added to the residue
- filtrationthe precipitated solid was recovered by filtration
출처 및 근거
- ORD 기록
- ord-fa7de088fada47f69ce40bd3dfec0682
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07622471B2
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