Hydrazine hydrate (1:1) → 2-Hydrazinyl-5-methoxypyridine

HRID 1437258노트

반응식

HRID 1437258 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][N:3]=1.O.[NH2:11][NH2:12]>>[NH:11]([C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][N:3]=1)[NH2:12]

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 151690002-Chloro-5-methoxypyridine

생성물 1

HCID 230902452-Hydrazinyl-5-methoxypyridine

실험 절차

The above-obtained 2-chloro-5-methoxypyridine (4.0 g) in hydrazine monohydrate (30 mL) was stirred at 100° C. for 24 hours, and then cooled in air. The reaction solvent was removed under reduced pressure, and the residue was partitioned by use of chloroform and aqueous 1N sodium hydroxide. The organic layer was dried over magnesium sulfate anhydrate, followed by filtration. The solvent was removed under reduced pressure, to thereby give 2-hydrazino-5-methoxypyridine as an oily product (705 mg, 18%).

후처리

  1. temperaturecooled in air
  2. customThe reaction solvent was removed under reduced pressure
  3. customthe residue was partitioned by use of chloroform and aqueous 1N sodium hydroxide
  4. dry with materialThe organic layer was dried over magnesium sulfate anhydrate
  5. filtrationfollowed by filtration
  6. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-5ef3b5688d254272ae3d74ff557b17fd
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622471B2

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