Isobutyl chloroformate → 7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]thiazin-2(3H)-one
반응식
[O:1]=[C:2]1[CH2:7][S:6][C:5]2[N:8]=[CH:9][C:10]([C:12](O)=[O:13])=[CH:11][C:4]=2[NH:3]1.C(OC(Cl)=O)C(C)C.[BH4-].[Na+]>>[OH:13][CH2:12][C:10]1[CH:9]=[N:8][C:5]2[S:6][CH2:7][C:2](=[O:1])[NH:3][C:4]=2[CH:11]=1참가 물질
4
실험 절차
The carboxylic acid (c) (2.48 g) was reacted with isobutylchloroformate and sodium borohydride by the method of Example (1i) to afford a solid (1.3 g), after recrystallisation from chloroform-methanol (9:1).
출처 및 근거
- ORD 기록
- ord-bba5c0adef1040c3b7cee492f38fd170
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07622481B2
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