Phosphoric Acid → HCID 74020140, 화합물

HRID 1437836노트

반응식

HRID 1437836 반응식
[Cl:1][C:2]1[C:3]([OH:25])=[C:4]([CH:12](O)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:5]([OH:11])=[C:6]([C:9]=1[CH3:10])[CH:7]=[O:8].P(=O)(O)(O)O>C(O)(=O)C>[Cl:1][C:2]1[C:3]([OH:25])=[C:4]([CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:5]([OH:11])=[C:6]([C:9]=1[CH3:10])[CH:7]=[O:8]

참가 물질

4

반응물 2

HCID 1004Phosphoric AcidHCID 23134889HCID 23134889, 화합물

생성물 1

HCID 74020140HCID 74020140, 화합물수율 76.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

5-Chloro-2,4-dihydroxy-3-(1-hydroxydodecyl)-6-methylbenzaldehyde (33 mg, 0.089 mmol) was stirred in acetic acid (2 ml) in the presence of 85% phosphoric acid (0.024 mmol) at a reflux temperature for 1.5 hours. The reaction mixture was cooled to room temperature. After extractive workup with ethyl acetate, the crude product was purified by silica gel thin-layer chromatography (chloroform) to obtain 5-chloro-3-(1-dodecenyl)-2,4-dihydroxy-6-methylbenzaldehyde (24 mg, yield 76%).

후처리

  1. customAfter extractive workup with ethyl acetate, the crude product was purified by silica gel thin-layer chromatography (chloroform)

출처 및 근거

ORD 기록
ord-77d53120d5eb4e29811c92ee2df0ed71
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622598B2

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