Iodoethane → Benzene, 2-ethoxy-4-iodo-1-(1-methylethoxy)-

HRID 1438097노트

반응식

HRID 1438097 반응식
[I:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH:10]([CH3:12])[CH3:11])=[C:6]([OH:8])[CH:7]=1.C([O-])([O-])=O.[K+].[K+].[CH2:19](I)[CH3:20]>CN(C=O)C.C(OCC)C>[CH2:19]([O:8][C:6]1[CH:7]=[C:2]([I:1])[CH:3]=[CH:4][C:5]=1[O:9][CH:10]([CH3:12])[CH3:11])[CH3:20]

참가 물질

6

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 58788960Phenol, 5-iodo-2-(1-methylethoxy)-

생성물 1

HCID 58788976Benzene, 2-ethoxy-4-iodo-1-(1-methylethoxy)-수율 98.4%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

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온도
40 °C

실험 절차

To a solution of 5-iodo-2-isopropoxyphenol (2.3 g, 8.3 mmol) in DMF (20 mL), K2CO3 (2.3 g, 16.5 mmol) and ethyl iodide (0.86 mL, 10.8 mmol) were added. The mixture was stirred at 40° C. for 2.0 h. It was diluted with diethyl ether, washed with brine, dried over MgSO4. The crude was purified by chromatography (5:1 EtOAc/hexanes) to give 2-ethoxy-4-iodo-1-isopropoxybenzene (2.5 g, 96% yield) as an oil.

후처리

  1. washwashed with brine
  2. dry with materialdried over MgSO4
  3. customThe crude was purified by chromatography (5:1 EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-70903fecf5bc4830847d08e50aa2db14
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622585B2

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