Potassium Cyanide → 2-(3-Difluoromethoxyphenyl)-2-hydroxyacetonitrile

HRID 1438170

반응식

HRID 1438170 반응식
[F:1][CH:2]([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH:7]=[O:8].[C-:13]#[N:14].[K+].OS([O-])=O.[Na+]>C(OCC)(=O)C.O>[F:1][CH:2]([F:12])[O:3][C:4]1[CH:5]=[C:6]([CH:7]([OH:8])[C:13]#[N:14])[CH:9]=[CH:10][CH:11]=1

참가 물질

6

반응물 3

HCID 9032Potassium CyanideHCID 27369853-(Difluoromethoxy)benzaldehydeHCID 23665763Sodium Bisulfite

생성물 1

HCID 544938472-(3-Difluoromethoxyphenyl)-2-hydroxyacetonitrile수율 92.9%

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To 3-difluoromethoxybenzaldehyde (1.77 g, 10 mmol) in ethyl acetate (25 mL) was added a solution of KCN (2.0 g) and NaHSO3 (3.2 g) dissolved in H2O (25 mL). It was left stirring overnight before it was extracted with ethyl acetate (2×50 mL). The combined organic extracts were dried and concentrated. The crude product was purified by silica gel chromatography to give 131A (1.85 g, 92% yield) as an oil.

후처리

  1. waitIt was left
  2. extractionwas extracted with ethyl acetate (2×50 mL)
  3. customThe combined organic extracts were dried
  4. concentrationconcentrated
  5. customThe crude product was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-6d746ab88683482984bcbc8e121a4e74
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622585B2

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