Methanol → 3,5-Diphenyl-4-propoxy-1H-pyrazole

HRID 1439127노트

반응식

HRID 1439127 반응식
[C:1]1([C:7]2[C:11]([OH:12])=[C:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O-].[Na+].CO.Br[CH2:25][CH2:26][CH3:27]>O>[CH2:25]([O:12][C:11]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8][NH:9][C:10]=1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[CH2:26][CH3:27]

참가 물질

6

반응물 4

HCID 887MethanolHCID 78401-BromopropaneHCID 3149543,5-diphenyl-1H-pyrazol-4-olHCID 10942334Sodium Methoxide

생성물 1

HCID 213980993,5-Diphenyl-4-propoxy-1H-pyrazole

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

A mixture of 3,5-diphenyl-4-pyrazolol (10 g, 0.042 mole), sodium methoxide (2.27 g, 0.042 mole) and methanol (60 ml) is heated at 60° C for 2 hours. Then 1-bromopropane (5.17 g, 0.042 mole) is added slowly (5 minutes) at 60° C. The reaction mixture is then held at 60° C until the reaction is complete by tlc. The mixture is poured into water and the solid formed is isolated by filtration. Recrystallization of the solid from acetonitrile affords white crystals, 7.4 g (63%), melting point 142°-142.5° C.

후처리

  1. customis then held at 60° C until the reaction
  2. customthe solid formed
  3. customis isolated by filtration
  4. customRecrystallization of the solid from acetonitrile
  5. customaffords white crystals, 7.4 g (63%), melting point 142°-142.5° C.

출처 및 근거

ORD 기록
ord-92ddf2b5968b4f3c91f4286a6aae35f0
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04058391

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