Chloroform → 3-(4,5-dichloro-1H-imidazol-2-yl)pyridine

HRID 1439247노트

반응식

HRID 1439247 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[NH:8]C=[CH:10][N:11]=2)[CH:2]=1.[Cl:12]N1C(=O)CCC1=O.[CH:20]([Cl:23])(Cl)Cl>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[NH:8][C:20]([Cl:23])=[C:10]([Cl:12])[N:11]=2)[CH:2]=1

참가 물질

4

반응물 3

HCID 6212ChloroformHCID 31398ChlorosuccinimideHCID 123955003-(1H-Imidazol-2-yl)pyridine

생성물 1

HCID 213989023-(4,5-dichloro-1H-imidazol-2-yl)pyridine

실험 절차

To a suspension of 2-(3-pyridyl)-imidazole (1.5 g., 0.01 moles) in chloroform (150 ml.) is added dropwise with stirring over one hour at reflux N-chlorosuccinimide (2.6 g., 0.02 moles). The reaction mixture is heated three hours at reflux. After cooling, the solvent is removed at 20 mm. and the residue triturated with water while heating on a steam bath. The resulting solid is filtered and after recrystallization from acetonitrile 400 mg. of 2-(3-pyridyl)-4,5-dichloroimidazole is obtained, m.p. 237°-238° C.

후처리

  1. additionis added dropwise
  2. temperatureThe reaction mixture is heated three hours
  3. temperatureat reflux
  4. temperatureAfter cooling
  5. customthe solvent is removed at 20 mm
  6. customand the residue triturated with water
  7. temperaturewhile heating on a steam bath
  8. filtrationThe resulting solid is filtered
  9. customafter recrystallization from acetonitrile 400 mg

출처 및 근거

ORD 기록
ord-6b62ec7126eb43fb85506213ab94d354
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04058614

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