Sodium Hydroxide → 8-Acetyl-8-phenyl-12-benzyloxyheptadecanoic acid

HRID 1439486노트

반응식

HRID 1439486 반응식
[C:1]([C:4]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([CH2:16][CH2:17][CH2:18][CH:19]([O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])(=[O:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([C:4]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([CH2:16][CH2:17][CH2:18][CH:19]([O:25][CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 21397385HCID 21397385, 화합물

생성물 1

HCID 213974108-Acetyl-8-phenyl-12-benzyloxyheptadecanoic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of ethyl 8-acetyl-8-phenyl-12-benzyloxyheptadecanoate (14 g., crude), sodium hydroxide (2.0 g., 0.05 mole) and methanol (150 ml.) is stirred for 48 hours. The methanol is removed in vacuo; and the residual oil is poured into H2O (100 ml.), acidified with 6 N HCl (100 ml.) extracted with ether, and the combined ether extracts dried over anhydrous Na2SO4. The ether is removed in vacuo, and the residual oil is chromatographed through a silica gel column (95% CHCH3 -5% MeOH) to obtain 8-acetyl-8-phenyl-12-benzyloxyheptadecanoic acid (1.43 g., slightly impure).

후처리

  1. customThe methanol is removed in vacuo
  2. additionand the residual oil is poured into H2O (100 ml.)
  3. extractionextracted with ether
  4. dry with materialthe combined ether extracts dried over anhydrous Na2SO4
  5. customThe ether is removed in vacuo
  6. customthe residual oil is chromatographed through a silica gel column (95% CHCH3 -5% MeOH)

출처 및 근거

ORD 기록
ord-7f6b93c755074f22a25bc718c4c81a11
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04059602

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