Hydrochloric Acid → HCID 20211459, 화합물

HRID 1439588노트

반응식

HRID 1439588 반응식
[Cl:1][C:2]1[C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:11].[S:12]1[CH:16]=[CH:15][CH:14]=[CH:13]1.Cl>C(Cl)Cl>[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:8]([C:7]1[C:2]([Cl:1])=[C:3]([CH3:11])[CH:4]=[CH:5][CH:6]=1)=[O:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8030ThiopheneHCID 193679402-Chloro-3-methylbenzoyl chloride

생성물 1

HCID 20211459HCID 20211459, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred and cooled mixture of 28.4 parts of 2-chloro-m-toluoyl chloride, 12.6 parts of thiophene and 80 parts of methylene chloride is added dropwise a mixture of 39 parts of stannic chloride in 40 parts of methylene chloride at 10° C. Upon completion, stirring is continued first for 2 hours at 20° C and further for 3 hours at reflux. The reaction mixture is poured onto a mixture of ice-water and concentrated hydrochloric acid solution. The methylene chloride solution is separated, washed three times with water, dried, filtered and evaporated. The residue is distilled, yielding 2-chloro-m-tolyl 2-thienyl ketone; bp. 197°-199° C at 12 mm. pressure.

후처리

  1. temperaturecooled
  2. additionis added dropwise
  3. stirringUpon completion, stirring
  4. temperatureat reflux
  5. customThe methylene chloride solution is separated
  6. washwashed three times with water
  7. customdried
  8. filtrationfiltered
  9. customevaporated
  10. distillationThe residue is distilled

출처 및 근거

ORD 기록
ord-fee4135229b34f4c839680967daa749f
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04060528

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