Ethylene Glycol → HCID 21396507, 화합물

HRID 1439765노트

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HRID 1439765 반응식
Cl[CH2:2][CH2:3][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)([OH:6])[CH3:5].[F-:20].[K+].C(O)CO>C(O)COCCO>[F:20][CH2:2][CH2:3][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)([OH:6])[CH3:5]

참가 물질

5

반응물 3

HCID 174Ethylene GlycolHCID 522689Potassium FluorideHCID 203028961-Chloro-3-(4'-fluoro-4-biphenylyl)-butan-3-ol

생성물 1

HCID 21396507HCID 21396507, 화합물

시약·촉매·용매 1

HCID 8117Diethylene Glycol용매

실험 절차

A mixture of 27.9 g. of 1-chloro-3-(4'-fluoro-4-biphenylyl)-butan-3-ol, 8.7 g. of KF, 10 ml. of ethylene glycol and 5 ml. of diethylene glycol is heated to 140° - 150° for 8 hours. It is cooled and worked up in the customary manner and gives 1-fluoro-3-(4'-fluoro-4-biphenylyl)-butan-3-ol, m.p. 90° - 92°.

후처리

  1. additionA mixture of 27.9 g
  2. temperatureIt is cooled

출처 및 근거

ORD 기록
ord-670ec53042604fe69402d0bc91ee2e7c
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04060633

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