Benzene → HCID 22800352, 화합물

HRID 1439805노트

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HRID 1439805 반응식
[OH:1][C@@H:2]1[CH2:6][C:5](=[O:7])[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:3]1.[CH:17]1[CH:22]=[CH:21][CH:20]=[CH:19]C=1.C1(C)C=CC(S(O)(=O)=[O:30])=CC=1.[O:34]1[CH:39]=[CH:38][CH2:37][CH2:36][CH2:35]1>C(OCC)(=O)C>[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH:39]1[O:1][C@@H:2]1[CH2:6][C:5](=[O:7])[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH:19]2[CH2:20][CH2:21][CH2:22][CH2:17][O:30]2)=[O:15])=[CH:3]1

참가 물질

6

반응물 4

HCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 162131497-[(3R)-3-Hydroxy-5-oxocyclopent-1-en-1-yl]heptanoic acid

생성물 1

HCID 22800352HCID 22800352, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 1.70 parts of 7-(3(R)-hydroxy-5-oxocyclopent-1-en-1-yl)heptanoic acid in 12 parts by volume of dry benzene is added 0.005 part of p-toluenesulfonic acid and 3.40 parts of dihydropyran. The reaction mixture is allowed to stand at room temperature for about 24 hours. The resulting solution is diluted with ethyl acetate, washed with water, dried over anhydrous sodium sulfate, and stripped of solvent under reduced pressure to afford tetrahydropyran-2-yl 7-(3(R)-tetrahydropyran-2-yloxy-5-oxocyclopent-1-en-1-yl)-heptanoate. This compound is represented by the following structural formula. ##STR21##

후처리

  1. washwashed with water
  2. dry with materialdried over anhydrous sodium sulfate

출처 및 근거

ORD 기록
ord-f22df2552fc84a519155c4d63e6b4c1d
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04060691

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