Triethylamine → N-(2,2,6-trimethyl-2,3-dihydrobenzofuran-7-yl)hexadecaneamide

HRID 1439929

반응식

HRID 1439929 반응식
[CH2:1]([C:17](Cl)=[O:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]C.[NH2:20][C:21]1[C:29]2[O:28][C:27]([CH3:31])([CH3:30])[CH2:26][C:25]=2[CH:24]=[CH:23][C:22]=1[CH3:32].C(N(CC)CC)C.C(=O)([O-])O.[Na+]>ClCCl>[CH3:30][C:27]1([CH3:31])[CH2:26][C:25]2[CH:24]=[CH:23][C:22]([CH3:32])=[C:21]([NH:20][C:17](=[O:18])[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:29]=2[O:28]1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 3516438Heptadecanoyl ChlorideHCID 106073987-Amino-2,2,6-trimethyl-2,3-dihydrobenzofuran

생성물 1

HCID 10835676N-(2,2,6-trimethyl-2,3-dihydrobenzofuran-7-yl)hexadecaneamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A 171 mg amount of hexadecanecarboxylic acid chloride was added to a solution of 100 mg of 7-amino-2,2,6-trimethyl-2,3-dihydrobenzofuran and 63 mg of triethylamine in 2 ml of dichloromethane, and the mixture was stirred at room temperature for one hour. A 10 ml amount of a saturated sodium hydrogencarbonate solution was added thereto, and the mixture was extracted twice with 20 ml of ethyl acetate.

후처리

  1. extractionthe mixture was extracted twice with 20 ml of ethyl acetate

출처 및 근거

ORD 기록
ord-b926b7ef2eaa4f22b4c8453c1d1c3211
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05496853

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