Hydrochloric Acid → Ramosetron Hydrochloride

HRID 1440043노트

반응식

HRID 1440043 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([C@@H:13]2[CH2:21][CH2:20][C:16]3[N:17]=[CH:18][NH:19][C:15]=3[CH2:14]2)=[O:12])=[CH:3]1.[ClH:22]>C(O)C.C(OCC)(=O)C.C(OCC)(=O)C>[ClH:22].[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([C@@H:13]2[CH2:21][CH2:20][C:16]3[N:17]=[CH:18][NH:19][C:15]=3[CH2:14]2)=[O:12])=[CH:3]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 108000Ramosetron

생성물 1

HCID 107999Ramosetron Hydrochloride

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 21584252Ethanol ethylacetate용매

실험 절차

In ethanol/ethyl acetate was dissolved 100 mg of (R)-(-)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole obtained in Example 43(b), and a solution of hydrogen chloride in ethyl acetate was added thereto. The thus formed crystal was collected and recrystallized from ethanol to obtain 70 mg of (R)-(-)-5-[(1-methylindol-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole hydrochloride.

후처리

  1. customThe thus formed crystal was collected
  2. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-8aff030058fb41aeb9c27cefb453352f
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05496942

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