Water → Imidazo[1,2-a]pyridin-6-ylmethanol

HRID 1440235

반응식

HRID 1440235 반응식
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH:10]=[O:11])[CH:7]=[CH:6][C:5]=12.[BH4-].[Na+].O.ClCCl.CO>CO>[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[C:8]([CH2:10][OH:11])[CH:7]=[CH:6][C:5]=12

참가 물질

6

반응물 4

HCID 962WaterHCID 4311764Sodium borohydrideHCID 7164582Imidazo[1,2-a]pyridine-6-carbaldehydeHCID 21226129Dichloromethane methanol

생성물 1

HCID 7060530Imidazo[1,2-a]pyridin-6-ylmethanol수율 57%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.90 g of the 6-imidazo[1,2-a]pyridinecarbaldehyde prepared in the Preparative Example 5 was dissolved in 20 ml of methanol. The obtained solution was stirred under cooling with ice, followed by the addition of 90 mg of sodium borohydride. The obtained mixture was stirred for 50 minutes, followed by the addition of water. The obtained mixture was extracted with chloroform. The organic phase was dried over anhydrous magnesium sulfate and distilled to remove the solvent. The obtained residue was purified by silica gel column chromatography [solvent: dichloromethane/methanol (30:1 to 10:1) to give 0.52 g of the title compound as a faintly orange-yellow solid (yield: 57%).

후처리

  1. temperatureunder cooling with ice
  2. stirringThe obtained mixture was stirred for 50 minutes
  3. extractionThe obtained mixture was extracted with chloroform
  4. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
  5. distillationdistilled
  6. customto remove the solvent
  7. customThe obtained residue was purified by silica gel column chromatography [solvent

출처 및 근거

ORD 기록
ord-41af41c29e0942c9ae91c5ee99e256c0
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05498634

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