Sodium Hydroxide → 2-{1-[(7-Chloro-1,8-naphthyridin-2-yl)amino]-6-methyl-3-oxoheptyl}benzoic acid

HRID 1440306노트

반응식

HRID 1440306 반응식
[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([N:12]3[C:20](=[O:21])[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]3[CH:22]([C:26](=[O:32])[CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])C(O)=O)=[N:9]2)=[CH:4][CH:3]=1.[OH-:33].[Na+]>O>[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([NH:12][CH:13]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=3[C:20]([OH:21])=[O:33])[CH2:22][C:26](=[O:32])[CH2:27][CH2:28][CH:29]([CH3:30])[CH3:31])=[N:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 18983252(+/-)-2-[2-(7-Chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-6-methyl-3-oxoheptanoic acid

생성물 1

HCID 98025152-{1-[(7-Chloro-1,8-naphthyridin-2-yl)amino]-6-methyl-3-oxoheptyl}benzoic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
20 °C

실험 절차

A suspension of 30 mg of (±)-2-[2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-6-methyl-3-oxoheptanoic acid in 4.7 cm3 of distilled water and 1.32 cm3 of a 0.1N aqueous sodium hydroxide solution is stirred at a temperature of approximately 20° C. for 72 hours. An insoluble product is removed by filtration and the filtrate is acidified to a pH=2 by addition of a 0.1N aqueous hydrochloric acid solution. The precipitate obtained is separated by filtration, washed with water and dried in air. 10 mg of (±)-2-{1-[(7-chloro-1,8-naphthyridin-2-yl)amino]-6-methyl-3-oxoheptyl}benzoic acid are thus obtained whose characteristics are identical to those of the product of Example 1.

후처리

  1. customAn insoluble product is removed by filtration
  2. additionthe filtrate is acidified to a pH=2 by addition of a 0.1N aqueous hydrochloric acid solution
  3. customThe precipitate obtained
  4. customis separated by filtration
  5. washwashed with water
  6. customdried in air

출처 및 근거

ORD 기록
ord-c056f0b9b2854032983d2e7383d78e55
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05498716

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