Hydrochloric Acid → HCID 19976901, 화합물

HRID 1440325노트

반응식

HRID 1440325 반응식
[CH2:1]([C:8]1[CH:12]=[C:11]([C:13](=[O:16])[CH2:14][CH3:15])[O:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:17].[NH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1.[CH2:24]=O.Cl>O1CCOCC1.C(OCC)C>[ClH:17].[CH2:1]([C:8]1[CH:12]=[C:11]([C:13](=[O:16])[CH:14]([CH3:24])[CH2:15][N:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[O:10][N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 2723721Piperidine, hydrochloride (1:1)HCID 19976952HCID 19976952, 화합물

생성물 1

HCID 19976901HCID 19976901, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

실험 절차

In 2 ml of dioxane, 1.5 g (7 mmol) of 3-benzyl-5-propionylisoxazole prepared above in the procedure (2), 0.93 g (7.7 mmol) of piperidine hydrochloride, 0.25 g (8.3 mmol) of paraformaldehyde and two droplets of 12N-hydrochloric acid were heated under reflux for 60 minutes. When left over in a cool place for 3 days after completion of the reaction, the reaction mixture became a solid. Diethyl ether was added to the solid. A solid was collected by filtration and then dried, whereby 3-benzyl-5-(2-methyl-3-piperidinopropionyl)isoxazole hydrochloride was obtained as colorless crystals.

후처리

  1. temperaturewere heated
  2. temperatureunder reflux for 60 minutes
  3. customafter completion of the reaction
  4. filtrationA solid was collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-3265bfb670bc40aeb0a0006974b19fca
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05498619

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