Sulfuric Acid → 1-tert-Butyl-5-(2-bromophenyl)-1H-tetrazole
반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][N:11]=[N:10][N:9]=1.[CH3:13][C:14](O)([CH3:16])[CH3:15].OS(O)(=O)=O>FC(F)(F)C(O)=O>[C:14]([N:9]1[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Br:1])=[N:12][N:11]=[N:10]1)([CH3:16])([CH3:15])[CH3:13]참가 물질
5
실험 절차
To a solution of 5-(2-bromophenyl)-1H-tetrazole (7.9 g, 0.035 mol) in trifluoroacetic acid (35 mL) was added tBuOH (5.2 g, 0.070 mol) and H2SO4 (1.0 mL, 0.0175 mol). After 18 h, the solution was concentrated and the residue was taken up in EtOAc. The mixture was washed with water, 2.5 N NaOH, water, dried (MgSO4), and concentrated. Purification by flash chromatography (20% EtOAc/hexane) gave 6.6 g (67%) of product as a pale yellow oil.
후처리
- concentrationthe solution was concentrated
- washThe mixture was washed with water, 2.5 N NaOH, water
- dry with materialdried (MgSO4)
- concentrationconcentrated
- customPurification by flash chromatography (20% EtOAc/hexane)
출처 및 근거
- ORD 기록
- ord-7a96e231205341d18bf548790214ba78
- 출처 데이터셋
- uspto-grants-1996_03
- 특허 번호
- US05498776
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