Triethylamine → Methyl 2-pentanoylaminothiophene-3-carboxylate

HRID 1440796

반응식

HRID 1440796 반응식
[C:1](Cl)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5].[NH2:8][C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15].C(N(CC)CC)C>ClC(Cl)C>[C:1]([NH:8][C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15])(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 78381Methyl 2-amino-3-thenoate

생성물 1

HCID 18982094Methyl 2-pentanoylaminothiophene-3-carboxylate수율 96%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

Valeryl chloride (1.3 g) was added to a solution of methyl 2-aminothiophene-3-carboxylate (1.6 g) [Y. Kuwada et al. Chem. Abst. 82, 156252(1975)] and triethylamine (1.2 g) in dichloroethane (20 ml) under ice-cooling. The mixture was stirred for two hours. The reaction mixture was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled under reduced pressure. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (2.3 g, 96%).

후처리

  1. washThe reaction mixture was washed with water
  2. dry with materialdried over anhydrous magnesium sulfate
  3. distillationThe solvent was distilled under reduced pressure
  4. customThe residue was purified by column chromatography on silica gel

출처 및 근거

ORD 기록
ord-a8d80564f5a44863b04abaf178b07cb0
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05500427

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