Hydrochloric Acid → Ecgonine methyl ester

HRID 1440977노트

반응식

HRID 1440977 반응식
[CH3:1][N:2]1[C@H:6]2[C@@H:7]([C:19]([O:21][CH3:22])=[O:20])[C@@H:8]([O:10]C(C3C=CC=CC=3)=O)[CH2:9][C@@H:3]1[CH2:4][CH2:5]2.Cl.Cl>O>[CH3:1][N:2]1[C@H:6]2[C@@H:7]([C:19]([O:21][CH3:22])=[O:20])[C@@H:8]([OH:10])[CH2:9][C@@H:3]1[CH2:4][CH2:5]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 656832(-)-Cocaine hydrochloride

생성물 1

HCID 104904Ecgonine methyl ester

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Cocaine hydrochloride (2.0 g) was dissolved in distilled water (100 ml) and concentrated hydrochloric acid (8.0 ml) and refluxed for 19 hours. After cooling to room temperature, the benzoic acid precipitated and was filtered. The filtrate was washed with chloroform to remove any remaining benzoic acid. The aqueous solution was evaporated to dryness in vacuo. The residue (ecgonine hydrochloride) was esterified by refluxing in methanolic hydrogen chloride (150 ml) for 17 hours. The solvent was removed in vacuo to yield ecgonine methyl ester as an oil.

후처리

  1. customthe benzoic acid precipitated
  2. filtrationwas filtered
  3. washThe filtrate was washed with chloroform
  4. customto remove any remaining benzoic acid
  5. customThe aqueous solution was evaporated to dryness in vacuo
  6. temperatureby refluxing in methanolic hydrogen chloride (150 ml) for 17 hours
  7. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-28ec9451232f47f78445d3a22fdfc220
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05501985

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