Acetic Acid → 2,6-Diisopropylphenyl acetate

HRID 1441136

반응식

HRID 1441136 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[OH:13])([CH3:3])[CH3:2].[C:14](O)(=[O:16])[CH3:15]>FC(F)(F)C(OC(=O)C(F)(F)F)=O.C(OCC)(=O)C>[C:14]([O:13][C:5]1[C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=[CH:7][C:6]=1[CH:10]([CH3:12])[CH3:11])(=[O:16])[CH3:15]

참가 물질

5

반응물 2

HCID 176Acetic Acid2회HCID 4943Propofol

생성물 1

HCID 5960912,6-Diisopropylphenyl acetate

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 9845Trifluoroacetic anhydride용매

실험 절차

A suspension of 2,6-diisopropylphenol (5.32 g) in 35 ml of trifluoroacetic anhydride is treated with 1.75 ml of glacial acetic acid under a nitrogen atmosphere. Upon completion of the addition of acetic acid, the solids are in mixture. Solvent evaporation gives an oil which is taken up in 150 ml of ethyl acetate and washed twice with saturated aqueous sodium bicarbonate and once with saline. Drying of the organic layer with sodium sulfate followed by filtration and solvent evaporation gives 6.55 g of an oil which is chromatographed on 330 g of silica gel eluting with chloroform/hexane (9/1). The appropriate fractions are pooled and concentrated to give the title compound, NMR (CDCl3, TMS) 7.2, 2.91, 2.36, 1.20.

후처리

  1. customSolvent evaporation
  2. customgives an oil which
  3. washwashed twice with saturated aqueous sodium bicarbonate and once with saline
  4. dry with materialDrying of the organic layer with sodium sulfate
  5. filtrationfollowed by filtration and solvent evaporation

출처 및 근거

ORD 기록
ord-47a25cf48a2a45d784aaad5f48237b27
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05502187

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