Fmoc-Gly-OH → L-Phenylalanine

HRID 1441193

반응식

HRID 1441193 반응식
[C:1]([N:18](C)[C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(N(C)[C@H](C(O)=O)CC(=O)OC(C)(C)C)(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.[NH:62](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:63]([C:68]([OH:70])=[O:69])[CH2:64][CH2:65][CH2:66][CH3:67].[NH:88](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:89]([C:100]([OH:102])=[O:101])[CH2:90][C:91]1[C:99]2[C:94](=[CH:95][CH:96]=[CH:97][CH:98]=2)[NH:93][CH:92]=1.N(C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)CC(O)=O>>[NH2:18][C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[NH:18]([CH3:1])[C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[NH2:62][C@H:63]([C:68]([OH:70])=[O:69])[CH2:64][CH2:65][CH2:66][CH3:67].[NH2:88][C@H:89]([C:100]([OH:102])=[O:101])[CH2:90][C:91]1[C:99]2[C:94](=[CH:95][CH:96]=[CH:97][CH:98]=2)[NH:93][CH:92]=1

참가 물질

9

반응물 5

HCID 93124Fmoc-Gly-OHHCID 978343Fmoc-L-tryptophanHCID 978356(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acidHCID 7009636(2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid2회HCID 7019716N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-alpha-methyl-L-aspartic acid beta-t-butyl ester

생성물 4

HCID 6140L-PhenylalanineHCID 6305L-TryptophanHCID 21236CaprineHCID 6951135N-Methylphenylalanine

실험 절차

By following essentially the procedure of Table 2 and sequentially coupling Fmoc-MePhe-OH, Fmoc-MeAsp(OtBu)-OH, Fmoc-Ahx-OH, Fmoc-Trp-OH, Fmoc-Gly-OH, Fmoc-Ahx-OH and Hpa-OSu, the title compound was prepared. Amino Acid analysis following acid decomposition gave MeAsp 1.01 (1), Gly 1.05 (1), MePhe 0.91 (1), Ahx 2.02 (2), Trp 0.84 (1), NH3 0.82. MS (FAB): m/e 909 (M-H)-.

출처 및 근거

ORD 기록
ord-0e70947c102c424092ae9d4f378d191a
출처 데이터셋
uspto-grants-1996_03
특허 번호
US05502164

연결된 노트

불러오는 중…