4-Toluenesulfonyl chloride → N-[5-bromo-3-hydroxypyridin-2-yl]-4-methylbenzenesulfonamide

반응식

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Br:12][C:13]1[CH:14]=[C:15]2[O:21]C(=O)[NH:19][C:16]2=[N:17][CH:18]=1.[OH-].[Na+]>>[Br:12][C:13]1[CH:14]=[C:15]([OH:21])[C:16]([NH:19][S:8]([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=2)(=[O:10])=[O:9])=[N:17][CH:18]=1

참가 물질

반응물 3

HCID 73974-Toluenesulfonyl chloride

HCID 14798Sodium Hydroxide

HCID 136144586-Bromo-3H-oxazolo(4,5-b)pyridin-2-one

생성물 1

HCID 23122883N-[5-bromo-3-hydroxypyridin-2-yl]-4-methylbenzenesulfonamide

실험 절차

With 4-methylbenzenesulfonyl chloride, 6-bromo-[1,3]-oxazolo[4,5-b]pyridin-2(3H)-one (described in Heterocycles, 41, 2799 (1995)) was allowed to react. Then, with an aqueous solution of sodium hydroxide, the mixture was hydrolyzed to give the title compound having the following physical data.