참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Acetamidine monohydrochloride | HCID 67170 | — |
| 반응물 | 2-Fluoro-4-nitrobenzaldehyde | HCID 4562919 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Methyl-7-nitroquinazoline | HCID 59164777 | 34.5% |
반응 단계
2-Fluoro-4-nitrobenzaldehyde (1.00 g, 5.92 mmol) and acetamidine hydrochloride (0.783 g, 8.28 mmol) were added to a suspension of activated 4 Å MS (1.2 g) in acetonitrile (60 mL). K2CO3 (1.14 g, 8.28 mmol) was then added and the reaction was heated to reflux for 4 h. The reaction was then cooled to 25° C. and filtered through celite rinsing with CH2Cl2. The crude product was purified by flash chromatography on silica eluting with 0-10% acetone in CH2Cl2 to give 0.386 g of compound 25A as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07655688B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_02 |
|---|
| ORD ID | ord-6049b3b6053640fbb4e80b2dc4f7fbbb |
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| 출처 메모 | uspto-grants-2010_02 |
|---|
