Sodium Hydroxide → HCID 59166768, 화합물
반응식
CC[O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([S:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)[CH2:8][N:7]1[C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:5].[OH-].[Na+]>CO>[C:22]([O:21][C:19]([N:7]1[CH2:8][C@@H:9]([S:11][C:12]2[CH:13]=[CH:14][C:15]([Br:18])=[CH:16][CH:17]=2)[CH2:10][C@H:6]1[C:4]([OH:5])=[O:3])=[O:20])([CH3:25])([CH3:23])[CH3:24]참가 물질
4
실험 절차
(2S,4S)-4-(4-Bromo-phenylsulfanyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester (Preparation 5, 120 mg, 0.30 mmol) was dissolved in MeOH (6 ml) and 2M sodium hydroxide was added (0.83 ml, 1.66 mmol). The solution was stirred for 14 h, concentrated and added to 0.5M HCl (50 ml). The aqueous was extracted with CH2Cl2 (50 ml) which was dried (magnesium sulphate) and concentrated. Flash column chromatography (eluting first with CH2Cl2 and then with 95% CH2Cl2/MeOH) gave the acid as a clear liquid (130 mg, 48%).